The invention discloses a resistance-reducing and antifouling coating composition and a resistance-reducing and antifouling coating prepared from the same. The composition contains a first component, a second component and a third component, wherein the first component is a polymer emulsion prepared through polymerization of acrylic acid monomers and epoxy monomers; the second component is microgel suspension liquid prepared through polymerization of substituted acrylamide, amphiphilic macromolecule monomers, a cross-linking agent and epoxy monomers; and the third component is a curing agent. The resistance-reducing and antifouling coating prepared from the components has thermosensitivity, and the surface of the coating is in a dynamic form under a temperature variation condition, so that the adhesion of living bodies is prevented, and the antifouling property is realized; and meanwhile, the coating layer has amphipathy, so that the resistance in a water medium is effectively reduced, and a resistance reduction effect is realized. By taking water as a solvent during the preparation of the composition and the coating, the composition and the coating are safe, environmentally friendly and free of pollution, the raw materials are easily available, a preparation method is simple, and large-scale production and application are easily realized.