The invention discloses a PVC drug packaging board cutting machine. The PVC drug packaging board cutting machine comprises a fixing base, wherein a packaging board accommodating groove is formed in the middle position at the top end of the fixing base; a first fixing plate vertically arranged is welded on one side at the top end of the fixing base; a second fixing plate vertically arranged is welded on the other side at the top end of the fixing base; a first sliding groove is formed in each of the adjacent sides of the first fixing plate and the second fixing plate; a support plate horizontally arranged is connected to the top ends of the first fixing plate and the second fixing plate; an air cylinder vertically arranged is mounted on each of the two sides at the bottom end of the support plate; a movable plate horizontally arranged is further arranged between the fixing base and the support plate; the two ends of the movable plate extend into the first sliding grooves separately; the movable plate is fixedly connected with the piston rods of the air cylinders; and a second sliding groove is formed in one side at the bottom end of the movable plate. The PVC drug packaging board cutting machine has the benefits as follows: the design is reasonable, drug packaging boards are cut conveniently at different positions, the labor operating cost is reduced, and the working efficiency of the cutting machine is effectively improved.