The invention discloses a PVC drug packaging box. The PVC drug packaging box comprises a drug packaging box body and a drug packaging box cover, wherein the drug packaging box cover is hinged to the upper part of the drug packaging box body; drug storage cavities are formed in the drug packaging box body; a buffer block is fixedly connected with the inner wall on one side of each of the drug storage cavities; a buffer groove is formed in one side of each of the buffer blocks; one end of a damping spring horizontally arranged is fixedly connected onto the inner wall on one side of each of the buffer grooves; and a clamping plate is fixedly connected to the other end of each of the damping springs. The PVC drug packaging box has the benefits as follows: the structure is simple, the design is reasonable, the buffer blocks, the buffer grooves, the damping springs and fixing pillars are arranged in the drug storage cavities, so that drugs can be effectively fixed and prevented from shaking and can also be taken and placed conveniently; besides, as damping plates are arranged, the pressure resistance and shock resistance of the PVC drug packaging box are effectively improved, and the damage of drugs caused by shaking and colliding during the conveying and selling processes is avoided.