Embodiments of the invention provide a method for green extraction and determination of a variety of compounds in the Chinese herbal compound drug Naoxintong. The method comprises the following steps: (1) acquiring liquid extract of a Naoxintong sample by using a matrix solid-phase dispersion extraction process, wherein the mass of the Naoxintong sample is 10-50 mg, an adsorbent is magnesium silicate, a mass ratio of the Naoxintong sample and the adsorbent is (2: 1) to (1: 5), an eluent is methanol with a concentration of 60% to 100 % and contains 0-0.2% by volume of formic acid, the ratio of the mass of the Naoxintong sample to an elution volume is 25-42 mg/mL, and grinding time of the Naoxintong sample and the adsorbent is 0-8 minutes; and (2) analyzing the liquid extract of the Naoxintong sample by using ultra-high performance liquid chromatography so as to determine the contents of the compounds in the Chinese herbal compound drug Naoxintong. The determination method provided by the invention can provide a theoretical basis for the validation studies of traditional Chinese medicines and provide technical support for the quality control of Naoxintong.