The invention discloses a power glitch detection circuit with an internal voltage regulator. The power glitch detection circuit with the internal voltage regulator comprises a voltage regulating module, a glitch detection module, a level conversion input module and a level conversion output module, wherein the voltage regulating module comprises the voltage regulator, and the voltage regulating module is used for generating a stable voltage output VR_OUT irrelevant to a chip high-voltage power supply VDDH; the glitch detection module is configured for detecting power glitch and outputting an alarm signal; the voltage output VR_OUT serves as a power supply of the glitch detection module; the level conversion input module is used for converting a digital signal from a Core power domain into a digital signal from a VR_OUT power domain; and the level conversion output module is used for converting the digital signal from the VR_OUT power domain into the digital signal from the Core power domain. The power supply of the power glitch detection circuit has relatively high independence and anti-interference performance, so that the stability and the reliability in the working process of the PGD circuit can be improved, the glitch attack responding speed is high, and the glitch trigger point judging accuracy is high.