The invention belongs to the technical field of inclined well construction, and discloses drilling fluid, and a local crushing formation inclined well inverse well guide hole drilling process adopting same. The drilling fluid comprises bentonite, a coating agent, inorganic salt, a viscosity/filtration loss reducer, a wall protective agent and water, and the components are in synergistic cooperation, so dispersion of clay and rock debris is effectively inhibited, the well wall stabilizing ability is improved and the downhole safety of well drilling is effectively guaranteed. According to the local crushing formation inclined well inverse well guide hole drilling process, the aims of carrying the rock debris and returning slag, balancing the pressure of the bottom layer, stabilizing the well wall and the like are fulfilled by injecting the drilling fluid provided by the invention; and the inverse well guide hole drilling process can perform construction in the fractured formation, so the construction efficiency is increased by above 25 percent and the application range of the reverse well method is widened.