The invention relates to a cross-laminated timber wall dovetail tenon connecting technology and a manufacturing method and belongs to the technical field of timber engineering. A cross-laminated timber wall dovetail tenon connecting structure comprises a dovetail tenon wall and a dovetail mortise wall. A dovetail tenon of the dovetail tenon wall is processed in the end face of cross-laminated timber in the longitudinal direction of the wall, a dovetail mortise of the dovetail mortise wall is milled in the plane of the cross-laminated timber in the longitudinal direction of the wall, and the dovetail tenon and the dovetail mortise are in angle fit to be processed. When a building of a timber structure is constructed, the dovetail tenon wall and the dovetail mortise wall are aligned to be driven in a hoisted mode, and accordingly connection is completed. The cross-laminated timber wall dovetail tenon connecting technology is mainly applied to connecting of the building walls of the cross-laminated timber structure, a mortise and tenon structure in an ancient building in China and a modern timer structure are combined, the strength requirement of a wall connecting joint can be met, factory prefabrication can be achieved, and rapid site construction can be achieved.