The invention discloses an oil-gas well serial double-submersible-electric-pump airtight production pipe column. The pipe column comprises a casing in an oil production well, an oil pipe in the casing, an underground safety valve which is arranged on the upper portion of the oil pipe and connected with a liquid control pipeline, and a casing packer which is arranged at the bottom of the oil pipe, internally provided with a positioning seal and a guide shoe and provided with a sealing cylinder; a cable production packer, an upper airtight electric submersible pump system, an underground tool direction adjusting device and a lower airtight electric submersible pump system are sequentially connected between the underground safety valve and the positioning seal in series from top to bottom. The upper and lower airtight electric submersible pump systems comprise airtight hangers and airtight system tanks connected with the lower portions of the airtight hangers. The packer is used for isolating stratum liquid from the portion, above the packer, of the casing at a deep position of a shaft, and casing protection liquid can be inserted into an annulus, between the oil pipe and the casing, above the casing packer, so that the production casing is effectively protected and prevented from being eroded by fluids high in sulfur content and high in corrosivity.