The invention relates to a hydraulic vertical rotation type anti-flooding protective air-tight door for rapid rail traffic engineering, and belongs to the technical field of protective air-tight doors. The door includes a door leaf, a door frame, a hinge, a blocking mechanism, a hydraulic driving device and an electric control system; the door leaf is connected with the door frame on one side through the hinge, one side of the door leaf is provided with the blocking mechanism, and the door leaf is connected with the hydraulic driving device; the hydraulic driving device is connected with the electric control system, the hydraulic driving device includes a base, a hydraulic cylinder, a first driving arm, a second driving arm, a rotating shaft and a supporting arm. According to the door, the requirement of the rail traffic large space vertical rotation type air-tight door for self weight and hydraulic door closing force are well met, so that the hydraulic driving device can be synchronously started and shut off, the situation that the air-tight door has uneven stress since upper driving force and lower driving force are different is prevented, and the door has good application prospects.