The invention discloses a microcosmic shakeout visualization simulation experiment device for a weakly-agglutinated sandstone oil reservoir and application thereof, and belongs to the technical field of microcosmic shakeout simulation experiment devices for oil reservoirs. The simulation experiment device includes a micro-imaging collecting system, a gas and liquid pumping system, a core slice model system and a sand collecting system; the core slice model system is provided with various core slice models in a parallel connection mode and is used for simulating different core states and shakeout rules; the gas and liquid pumping system can conduct shakeout simulation experiments of core injection in a pure liquid phase, a pure gaseous phase, a gas and liquid mixture mode and a solid and liquid mixture mode, and is used for simulating different production conditions; by utilizing the device for conducting experiments, a microcosmic desquamation process of sand grains, transfer and blockage processes of the sand grains in a pore throat, a core shakeout mechanism of the sand grains and shakeout form rules of the sand grains can be analyzed in a visualized mode, so that mechanism researches are carried out on the shakeout of a loose sandstone stratum and a hydrate reservoir stratum, and theoretical bases are provided for efficient development of the loose sandstone stratum and the hydrate reservoir stratum.