The invention relates to a layout device of low-voltage cables in a communication machine room and belongs to the technical field of fixation of cables in communication machine rooms. The layout device is formed by a machine base, a baseplate, a partition plate, a top plate and lock catches, wherein the baseplate is mounted on the machine base, the partition plate and the top plate are mounted on the upper portion of the baseplate in sequence, the lock catches are mounted at two ends of the baseplate, the partition plate and the top plate, and cable fixing holes are formed among the baseplate, the partition plate and the top plate. The layout device is simple in structure and convenient to operate, the cables can be put into cable pressing holes during work and fixed by cable fixators, so that the cables are prevented from winding mutually when the layout work of low-voltage cables is conducted, and the layout device is beneficial for binding of the cables. According to the layout device of the low-voltage cables in the communication machine room, the lengths of the baseplate, the partition plate and the top plate can be increased and then the number of the pressure line holes can be increased according to the requirements, and the layout device can be suitable for binding of the low-voltage cables with different specifications. The problems are solved that the cables mutually wind when the the layout work of low-voltage cables is conducted and accordingly the cable layout work efficiency is low and the work intensity is high.