The invention relates to a key node recognition method for a regional power grid, and the basic flow of the method comprises the steps: inputting a power system topological structure and electrical characteristic parameters; calculating the values of evaluation indexes of a node; obtaining a node importance evaluation decision making matrix according to the values of the evaluation indexes; generating a node importance evaluation decision making matrix of a standard regional power grid; giving consideration to a Gini coefficient and a Kendall correlation coefficient, and solving the objective weights of the indexes through a CRITIC method; and solving an evaluation result of the node importance through a TOPSIS method. According to the technical scheme of the invention, the method gives full consideration to the physical features of the network topological structure and the operation state parameters of the power grid. The method can achieve the better recognition of the key node of the power grid, avoids the subjectivity of manual determination of the weights, and enables an evaluation result to be more suitable for the actual operation conditions of the power grid.