The invention provides a node active power adjustment method and system considering large-scale power loss. The method includes the following steps: determining grid computing nodes according to equipment constituting the grid, and constructing a node active power adjustment model based on the grid computing nodes; and when there is power loss, calculating the active power adjustment quantity of each node based on the node active power adjustment model, and assigning the active power adjustment quantity to specific equipment. Through the method and the system, the adjustment resources of DC inverter stations, local dispatching small power supplies and schedulable loads can be all considered quickly, and adjustable resources can be called reasonably and intervened flexibly. The adjustment quantity of the nodes is calculated first, and then assigned to specific grid equipment. The computation scale can be reduced, and the computation speed can be increased.