The invention provides a comprehensive prevention and control method for sunflower field weeds and relates to the technical field of sunflower cultivation. The comprehensive prevention and control method comprises the steps that firstly, a non-selective herbicide is sprayed to planting soil in a field to remove weeds, then sunflowers are planted, a selective herbicide safe to dicotyledons is sprayed to the planting soil for treatment before sunflower seedling emergence, a stem leaf herbicide is sprayed to sunflower stems and leaves for treatment at the stage when each seedling have 7-8 leaves after sunflower seedling emergence. According to the method, the multiple herbicides are adopted and sprayed to the planting soil or plants at different herbicide planting stages, the method has the advantages of preventing and controlling a variety of weeds, being good in prevention and control effect and harmless to sunflower plants, making weed damage not recrudescent again and the like, and the problem is effectively solved that an existing sunflower field weeding technique prevents and control fewer types of weeds, is poor in prevention and control effect and likely causes recrudescent weed damage.