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发明公开
CN107485616A 矢车菊素-3-O-葡萄糖苷在制备3-氯-1,2-丙二醇引发的疾病药物中的应用 无效 - 驳回

矢车菊素-3-O-葡萄糖苷在制备3-氯-1,2-丙二醇引发的疾病药物中的应用
摘要：
本发明提供了矢车菊素-3-O-葡萄糖苷在制备和/或预防3-氯-1,2-丙二醇引发的生殖疾病药物中的应用。本发明发现，矢车菊素-3-O-葡萄糖苷（C3G）可以改善3-MCPD染毒造成的大鼠摄食减少，生长迟缓状况；并且可以有效拮抗3-MCPD染毒造成的大鼠抗氧化系统破坏，通过抑制MAPK信号通路激活调节支持细胞BTB结构功能，来减轻3-MCPD造成的生精上皮损伤，维持生精微环境稳定并调节生精细胞分裂与分化，改善生精障碍。同时C3G可以通过调节精子能量代谢相关酶，提高精子活性。调节3-MCPD染毒造成的大鼠性激素分泌紊乱，维持血清性激素与睾丸内环境中雄激素正常水平。本发明为以后花色苷对3-MCPD生殖毒性营养干预提供理论基础。
摘要（英）：

Applications of cyanidin-3-O-glucoside in preparation of medicines treating and/or preventing diseases caused by 3-chloropropane-1,2-diol are provided. The cyanidin-3-O-glucoside (C3G) can improve rat ingestion decrease and growth retardation which are caused by 3-MCPD poisoning, can effectively resist rat antioxidant system damage caused by 3-MCPD poisoning, and can activate and adjust BTB structural functions of sustentacular cells through inhibiting an MAPK signaling pathway, thus relieving seminiferous epithelium injuries caused by the 3-MCPD, maintaining stability of a spermatogenic microenvironment, regulating spermatogenic cell proliferation and differentiation, and improving dyszoospermia. In addition, the C3G can improve sperm activity through adjusting sperm energy metabolism related enzymes. The C3G can regulate rat sex hormone secretion disorders caused by 3-MCPD poisoning and can maintain normal levels of sex hormone in serum and androgen in testis inner environments. The applications provide theoretical foundations for 3-MCPD reproduction toxicity nutritional intervention utilizing anthocyanin.

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