The invention discloses a hole sealing and dust prevention processing technique for a mobile phone shell. The hole sealing and dust prevention processing technique for the mobile phone shell comprises the following steps that S10, threaded holes of the mobile phone shell are filled with liquid hydrosol; S20, the hydrosol in the threaded holes is cured at a high temperature; S30, sand blasting is conducted on the surface of the mobile phone shell; S40, the mobile phone shell is washed through water to remove the hydrosol in the threaded holes; and S50, the mobile phone shell is dried. According to the hole sealing and dust prevention processing technique for the mobile phone shell, the threaded holes in the mobile phone shell are sealed through the hydrosol before sand blasting is performed on the mobile phone shell, the hydrosol in the threaded holes is removed through water after sand blasting is performed, and thus foreign matter like sand grains and dust generated during sand blasting is prevented from entering the threaded holes; and besides, the hydrosol for sealing the threaded holes can be quite easily removed, and the connection effect of the threaded holes and screws is ensured.