The invention discloses a high-voltage isolation high-power equipment cooling system, and belongs to the technical field of high-power equipment cooling. The high-voltage isolation high-power equipment cooling system comprises high-power to-be-cooled equipment, a circulation water cooler, a high-voltage shielding cabin arranged on the periphery of the high-power cooling equipment, a high-voltage insulating supporting column arranged at the bottom end of the high-voltage shielding cabin, and an electric ion exchange apparatus which is connected with the circulation water cooler and used for maintaining the cooling water therein at a high-resistance state; in general, according to the scheme, the cooling water in the circulation water cooler in the ground potential is subjected to cation and anion exchange to maintain the resistivity of the cooling water; the cooling water in the ground potential is conveyed to a high potential through an insulating pipeline and cooling water is provided for the equipment in the high potential; the deionized water after passing through the equipment is returned from the high potential to the water cooler in the ground potential through the insulating pipeline, so that recycling of the deionized water is realized; the whole system is simple in structure and safe and reliable; and compared with the conventional cooling mode, energy can be saved greatly in the cooling system disclosed in the invention.