The invention discloses a gentle method for carbonylation and arylation reaction of urea compounds. The method includes a step of performing a coupling carbonylation reaction to a halogenated aromatic compound with a urea compound under a gentle condition to produce a ureide compound, palladium acetate being a catalyst, triethylamine being an alkali, and pentacarbonyl iron being a CO release source. The method has simple operations and gentle reaction condition, is low in usage amount of the catalyst and the CO release source, is low in toxicity and cost, has wide substrate applicability and high yield of the target product, and can be widely applied to preparation of a ureide compound medicine molecule.