The invention discloses a method of detecting salt lake brine by a seismic method. The method comprises steps: the morphology of a research area and a subsidence center are analyzed; in a selected exploration range, the geological structure and the mineral distribution condition in a work area are judged; fractures in the research area are divided; a nuclear magnetic resonance method is used to determine a watery area; a mining well location is determined; and hydrogeology drilling is used to verify the determined watery area. The watery area can be deduced, the mining well location is determined, the hydrogeology drilling is used to verify the determined watery area, the water inflow is large, and the water quality is good.