The invention discloses a multiple-interruptible-load real-time coordination control method considering a market operation rule. The method comprises the following steps of 1) carrying out spectral analysis on interruptible loads, according to different demand response time in a distribution network, carrying out detailed classification on the interruptible loads of residents and using a frequency domain to represent each type of interruptible loads; 2) determining a control target and establishing an assessment standard, taking one day as one scheduling period, dividing into 96 point assessment periods, guiding a system to appropriately schedule the interruptible loads, and simultaneously verifying a compensation effect of each assessment period; 3) carrying out real-time demand-based control, according to a power deviation value, using discrete Fourier transformation to calculate scheduling amounts of various kinds of interruptible loads, and under limitation of three control threshold values, compensating a power deviation in real time; 4) correcting a scheduling demand value, and according to an actual condition, adjusting the scheduling amount and a scheduling frequency of each interruptible load; and 5) investigating a correction effect, controlling the assessment standard according to a feed line and investigating the correction effect of each period.