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发明授权
CN107523136B 温度响应性可降解3D打印生物墨水及3D打印方法 有权

温度响应性可降解3D打印生物墨水及3D打印方法
摘要：
一种温度响应性可降解3D打印生物墨水及3D打印方法，所述3D打印生物墨水由温度响应性水凝胶和生物细胞构成，所述水凝胶由具有温度响应性的PLGA‑PEG‑PLGA三嵌段共聚物按照一定比例与其他添加物混合制成，由于温度响应性的PLGA‑PEG‑PLGA三嵌段共聚物的临界相转变温度范围为20‑33℃，具有在人体体温37℃的固化成凝胶特性，从而使得本发明的3D打印生物墨水具备了同样的温度响应性及可降解特性。本发明利用上述3D打印生物墨水的温度响应性以及可降解特性，在打印之前配制预凝聚的生物墨水，打印之后对模型缓慢冷冻之后快速升温脱出水分，可以形成含有生物细胞的多孔的结构模型，可以获得多孔结构的营养和代谢通道，有利于通过3D打印获得更大更厚的组织结构。
摘要（英）：

The invention discloses temperature-responsive and degradable 3D printing bio-ink and a 3D printing method. The 3D printing bio-ink is composed of a temperature-responsive hydrogel and biological cells, wherein the hydrogel is prepared from a PLGA-PEG-PLGA triblock copolymer with the temperature responsibility and other additives through mixing in a certain ratio. The critical phase transformation temperature range of the PLGA-PEG-PLGA triblock copolymer with the temperature responsibility is 20-33 DEG C and the PLGA-PEG-PLGA triblock copolymer has the characteristic of being cured into gel at the human body temperature of 37 DEG C, so that the 3D printing bio-ink has the same temperature-responsive and degradable characteristics. The pre-condensed bio-ink is prepared before printing by use of the temperature-responsive and degradable characteristics of the 3D printing bio-ink, rapid heating and dewatering are performed after a model is slowly frozen after printing, a porous structural model containing the biological cells can be formed, nutrition and metabolic channels with porous structures can be obtained, and larger and thicker tissue structures are advantageously obtained through 3D printing.

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