The invention discloses a high-efficiency degrading strain of medroxyprogesterone acetate and application of such high-efficiency degrading strain and belongs to the technical field of biotreatment of environmental organic pollutants. The high-efficiency degrading strain named as Solibacillus silvestris MPA3 is derived from washing water of a large-scale pig farm in Foshan, Guangdong province, is obtained from manual enrichment culture, separation and purification and is preserved with the number GDMCC NO: 60209 in Guangdong Institute of Microbiology, Floor 5, Building 59, Courtyard 100, Xianlie Mid Road, Guangzhou in June 30, 2017. The high-efficiency degrading strain of the medroxyprogesterone acetate has the advantages that the high-efficiency degrading strain is high in degrading rate, can be used for degrading single medroxyprogesterone acetate and various steroid hormone mixed pollutants and provides a novel germplasm resource for treating municipal sewage and aquaculture sewage containing the medroxyprogesterone acetate.