The invention discloses a wind-power-participation real-time control method. The method comprises the following steps of firstly, acquiring a net load increment prediction value and a target function value of a control unit; calculating a marginal cost target value of the control unit; then modifying a system power vacancy and an operation basic point; correcting operation basic points of an AGC set and a wind power plant and the system power vacancy; finally, determining whether the system power vacancy is zero and the target function value of each local control unit is not changed; and if the system power vacancy is not zero and the target function value of each local control unit is changed, returning to a step S1 and carrying out next iteration, and if the system power vacancy is zero and the target function value of each local control unit is not changed, according to a final result, correcting the operation basic points of the wind power plant and the AGC set. By using the method of the invention, through a wind power plant and AGC set distributed cooperation real-time control model, under large scale wind power integration, real-time control is performed, and the net load increment prediction value is distributed between a conventional AGC set and the wind power plant through an equal marginal cost rule so as to reduce system operation cost and increase a system wind power consumption capability.