A multifunctional thrombus fragmentation and thrombectomy device comprises a plastic elastic cannula on the outer side, a rotating tube on the inner side, and a rotating operation mechanism. Accordingto the multifunctional thrombus fragmentation and thrombectomy device, friction removal is conducted on thrombus on the inner wall of a blood vessel through a mesh-shaped expansion head; the expansion head is in a mesh shape and can be compressed to deform under the excessive resistance instead of injuring the inner wall of the blood vessel, the diameter of the expansion head can be controlled through the relative position of a pull wire and the rotating tube, and flexibility is higher.