The invention belongs to the technical field of catalyst material, and provides a supported catalyst used for large molecular amine-terminated polyether (molecular weight ranges from 1000 to 5000). The supported catalyst is Ni/Al2O3. A catalyst active component is nanometer-grade nickel oxide synthesized via hydrothermal method, and carrier aluminium oxide is macroporous gamma-aluminium oxide synthesized via hydrothermal method. The supported catalyst comprises, by mass, 20 to 35% of metal nickel, and 65 to 80% of Al2O3. The supported catalyst is used for synthesis of amine-terminated polyether, conversion rate is high, selectivity is high, reaction conditions are mild, and application prospect is promising.