The present invention provides a well-constrained structural interpretation layer depth system correction method. The method comprises: the step 1, performing seismic horizon interpretation accordingto logging data of a drilled well; the step 2, performing fault interpretation, performing fault combination on a plane after interpretation is completed on a seismic section; the step 3, performing preliminary construction and mapping of an interpreted horizon; and the step 4, employing real depth of the drilled well to perform error correction after the preliminary construction and mapping to obtain a relatively accurate structural map. The well-constrained structural interpretation layer depth system correction method effectively solves the problems that a structural map is not matched withthe real depth of a drilled well and structural features are greatly different from a reality, especially, the well-constrained structural interpretation layer depth system correction method has an important meaning for a region with a high exploration degree, is simple and practical and high in operability and has a good popularization prospect.