The invention discloses natto powder essence for anti-bloodshot mask. The essence disclosed by the invention is a mixed solution prepared from a plant extracting solution, natto powder and an auxiliary agent, wherein the weight ratio of the plant extracting solution to the natto powder to the auxiliary agent is (3 to 6) to (2 to 4) to 1; the enzyme activity of the natto powder is 2000FU/g to 2500FU/g; the auxiliary agent is prepared from the following components in parts by weight: 12 to 18 parts of silk protein, 1 to 4 parts of vitamin C, 1 to 8 parts of aspartic acid, 5 to 14 parts of carboxymethylcellulose sodium, 1 to 3 parts of cod-liver oil, 0.2 to 0.8 part of dexamethasone and 0.01 to 0.03 part of nano silver. Compared with the prior art, the natto powder essence disclosed by the invention has long moisture-keeping time and has the treatment effects of naturally whitening, removing wrinkles, firming and lifting, resisting bacteria, relaxing and the like.