The invention relates to a clamp, in particular to a horizontal processing center multi-station clamp, and belongs to the technical field of a horizontal processing center. The horizontal processing center multi-station clamp comprises a bottom plate, an upper baffle plate, an upper pressing block, an upper pad plate, a lower baffle plate, a lower pressing block and a lower pad plate; the upper baffle plate, the upper pressing plate, the upper pad plate and the lower pad plate are arranged on the surface of the front end of the bottom plate sequentially from top to bottom; an upper pressing block cavity is formed in the upper pad plate; the upper pressing plate is arranged in the upper pressing block cavity; the upper pressing block is connected onto the upper pad plate through a first adjusting screw rod; a first locking block and a second locking block are arranged in the upper pressing block cavity; and the end faces, matched with the upper pressing block, of the first locking blockand the second locking block are inclined surfaces. Due to the inclined surface extrusion and clamping mode, clamping stability and reliability are achieved; locking can be finished only by adjustingthe two screw rods, so that the clamping time is shortened; the clamping times are reduced, the knife changing times are reduced, the processing efficiency and the processing stability of products are improved, and the processing cost is reduced; and the toothed screw rod can prevent slippage of the clamped workpiece.