The invention provides a wipe control system and method for a block region of a windshield. The system comprises an image shooting device, a block region identification module and a windshield wiper controller, wherein the image shooting device is aligned to the windshield and shoots images in real time, so that original images at least containing a windshield wiper region are continually obtained; the block region identification module receives the original images in real time, identifies the block region in the original images and locates the coordinate and the region range of the block region in the original images; a plurality of branch wipe regions used for dividing the windshield wiper region are arranged in the block region identification module in advance, the corresponding branchwipe regions is selected according to the coordinate and the region range so as to generate a first block region characteristic value and generate a first branch wipe instruction; the windshield wipercontroller determines the upper and lower limit range of a windshield wiper according to the first block region characteristic value, adjusts the upper and lower limit range of a windshield wiper according to the change of the first block region characteristic value, and at least responds to the first branch wipe instruction to control the windshield wiper to wipe repeatedly in the upper and lower limit range of the windshield wiper. By means of the wipe control system, it is achieved that obstructions are quickly wiped, so that it is avoided that the obstructions have an impact on driving safety.