The invention relates to a quinazoline derivative shown as a formula (I), a preparation method of the quinazoline derivative, a medicine combination containing a compound shown as the formula (I), andapplication of the medicine combination to preparation of medicine for treating and preventing tumor. The compound can irreversibly prevent self phosphorylation of EGFR and can effectively inhibit the signal conduction of cancer cells; higher in vitro and in vivo antitumor activity is shown. (The formula (I) is shown in description.).