The invention belongs to the field of superconducting electrical technology, and particularly relates to a cable-in-conduit conductor based on ReBCO isotropic superconducting strands. In view of the disadvantages of the existing cable-in-conduit conductor prepared from a low-temperature superconductor, such as low critical current density, low critical magnetic field intensity, low operating temperature, small temperature field and poor mechanical property, the invention presents a cable-in-conduit conductor based on ReBCO isotropic superconducting strands. The cable-in-conduit conductor is composed of a center conductor, ReBCO isotropic superconducting strands, a metal sheath, and a cooling channel. The ReBCO isotropic superconducting strands are closely arranged and spirally wound aroundthe center conductor as sub strands. Complete transposition can be realized for the ReBCO isotropic superconducting strands. The cable-in-conduit conductor has the advantages of good critical currentisotropy, high operating temperature, high operating current density, simple production process, suitability for large-scale production, and the like. The application of ReBCO isotropic superconducting strands in nuclear fusion large-scale superconducting magnet coils and other high-energy physical devices is expanded.