The invention discloses a preparation method of 2,5-disubstituted oxazole compounds. N-(propargyl) arylamide and aryl chloride are catalyzed by ferric iron compounds to generate a cyclization couplingtandem reaction, a series of oxazole compounds are generated by a one-step method, and the yield of the oxazole compounds is 83% to 95%. The method has simple operation, simple raw materials and reagents and higher reaction yield, avoids the disadvantages of the traditional method of troublesome precursor preparation, expensive catalysts and harsh conditions, has easy separation and purificationof the products and is suitable for various substituted oxazole compounds.