The invention belongs to the technical field of traditional Chinese medicine preparations, and specifically discloses a preparation with the effect of reducing blood glucose and blood fat and a preparation method of the preparation. The preparation mainly comprises the following raw materials in parts by weight: 3 to 10 parts of hawthorn, 5 to 15 parts of Chinese yam, 3 to 5 parts of fruit of Chinese wolfberry, 5 to 15 parts of sweet Chinese catalpa grass, 5 to 20 parts of root of kudzu vine, 10 to 20 parts of gynostemma pentaphylla, 0.1 to 0.5 part of corn stigma, 1 to 3 parts of vernoniaamygdalina del leaves, 2 to 6 parts of butterflybush flower, 0.001 to 0.005 part of eleutheroside, 0.03 to 0.07 part of soy isoflavone, 1 to 5 parts of oxidized konjac glucomannan and 0.05 to 0.5 part offermented soya bean fibrinolytic enzyme. According to the traditional Chinese medicine preparation provided by the invention, the blood viscosity can be effectively improved, the blood glucose and blood fat are reduced, and the metabolic activity of fat is strengthened; partial raw materials come from food, the preparation is safe without side effect, and the preparation is convenient to take andgood in taste; and the preparation can be mixed with flour and buckwheat powder in a certain proportion, so that a health food capable of reducing blood glucose and blood fat is prepared.