The invention discloses an antibacterial and deodorant toilet cleaner and a preparation method thereof. The antibacterial and deodorant toilet cleaner is prepared by pressing medicine powder and auxiliary materials, wherein the medicine powder comprises the following components: by weight, 3-10 parts of pomegranate peel extract, 5-20 parts of lemon mint extract, 3-10 parts of brucea javanica extract, 2-5 parts of berberine, 1-3 parts of bacillus licheniformis and 52-86 parts of magnesium stearate. The preparation method of the antibacterial and deodorant toilet cleaner comprises the followingsteps of: (1) mixing the components of the medicine powder in proportion, pouring the components through a 50 mesh sieve, adopting 10% starch paste as a binder to prepare a soft material, drying the soft material at 40-60 DEG C for 1-3 hours, pouring the dried soft material through a 20 mesh sieve, and collecting whole particles to obtain the particles; and (2) mixing the particles with disintegrant sodium carboxymethyl cellulose and filler microcrystalline cellulose according to a ratio of 1:(2-4):(3-5), putting the obtained mixture into a mold, and conducting compression moulding. The antibacterial and deodorant toilet cleaner has the advantages of fragrant smell and a function of deordorization and sterilization, and is non-toxic and smells fragrant.