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发明公开
CN107586849A 脑组织来源的circ9:4117768|4118881的应用 无效 - 驳回

脑组织来源的circ9:4117768|4118881的应用
摘要：
本发明公开了一种脑组织来源的环状RNA(circular RNA，circRNA)circ9:4117768|4118881的应用方法，即检测脑组织中circ9:4117768|4118881表达量的试剂在制备胶质瘤诊断制剂中的应用。该circRNA此前并未报道研究过，通过研究证实采集胶质瘤患者胶质瘤组织后提取RNA，逆转录并进行实时荧光定量分析发现circRNAcirc9:4117768|4118881表达水平下降。通过检测胶质瘤患者胶质瘤组织中circRNAcirc9:4117768|4118881的表达水平，从而对胶质瘤患者做出诊断判断。
摘要（英）：

The invention discloses an application method of a brain tissue-derived circular RNA (circularRNA, circRNA) circ9:4117768|4118881, that is, the application of a reagent for detecting the expression quantity of circ9:4117768|4118881 in brain tissue to preparation of a glioma diagnosis preparation. The circRNA has not been reported or studied before. Studies prove that the expression level of the circRNA circ9:4117768|4118881 is reduced after RNA is extracted from collected glioma tissue of a glioma patient and subjected to reverse transcription and real-time fluorescence quantification analysis. By detecting the expression level of the circRNA circ9:4117768|4118881 in glioma tissue of a glioma patient, the glioma patient can be diagnosed.

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