The invention relates to an SCR denitration catalytic grid brick for a coke oven and a preparation method of the grid brick. The grid brick comprises a grid brick matrix and an active component, wherein the grid brick matrix is prepared from a silicon-aluminum refractory material, and the active component is formed by mixing one or more selected from a group consisting of V2O5, WO3, CuO, CrOx, MnOx, MoO3 and NiO; the active component is loaded on the grid bricks through an impregnation or precipitation method; and the reaction temperature of the denitration catalytic action of the grid brick is in a range of 250-500 DEG C. According to the invention, the original heat exchange performance of the grid brick is maintained, and the SCR denitration catalytic effect is achieved, so that the requirement for reducing the emission of the flue gas nitrogen oxides of the coke oven can be met, and the investment and operation costs are not increased.