The invention discloses a preparation method and application of a ruthenium, cerium and zirconium-containing solid solution catalyst. The preparation method of the ruthenium, cerium and zirconium-containing solid solution catalyst comprises the following steps: firstly, dissolving ceric ammonium nitrate, zirconium oxychloride and lanthanum nitrate in a certain ratio into deionized water; then, adding 1 to 20 weight percent of ammonia water slowly to regulate the pH value of the solution to be 1.5, standing for 12 to 72 hours at 30 to 80 DEG C, adding urea and 5 percent ruthenium chloride solution, and mixing uniformly; next, insulating the heat of the mixed solution for 4 to 36 hours at 120 to 200 DEG C; finally, performing centrifuging, washing, drying and baking an obtained precipitate to obtain the ruthenium, cerium and zirconium-containing solid solution catalyst. The preparation method is simple in production process, economical and environment-friendly; moreover, the high-temperature heat stability is high; the prepared ruthenium, cerium and zirconium-containing solid solution catalyst can be applied to the fields of catalytic purification of automobile exhaust and dry gas reforming reaction of methane.