The invention discloses an injection mold guide system based on air flow intelligent guide. An injection mold comprises a fixed die and a movable die; the injection mold guide system based on air flowintelligent guide comprises a plurality of guide grooves and a plurality of guide end bodies which are arranged on the fixed die and the movable die correspondingly, and the multiple guide grooves correspond to the multiple guide end bodies on a one-to-one manner; and a guide cavity of a hollow structure is arranged inside each guide end body, a first air flow pipe extending to the end of the corresponding guide end body and a second air flow pipe extending to the connecting position of the corresponding guide end body and the movable die are arranged in each guide cavity, and an air pump isarranged inside each guide cavity. By means of the injection mold guide system based on air flow intelligent guide, the guide effect of the fixed die and the movable die can be improved, and the separating effect in the molding separating process can be improved.