The invention discloses an unmanned aerial vehicle express receiving cabinet. The unmanned aerial vehicle express receiving cabinet includes a cabinet body and a control device; the control device isarranged in the cabinet body; the cabinet body includes a storage cabinet and a plurality of replenishment devices; the control device is connected to the replenishment devices; every two adjacent replenishment devices form a storage layer; the plurality of the storage layers form the storage cabinet; and each replenishment device includes a first replenishment plate and a second replenishment. The unmanned aerial vehicle express receiving cabinet receives a replenishment signal sent by an unmanned aerial vehicle via the control device and sends the replenishment signal to the replenishment devices; the replenishment devices drive the first replenishment plates and the second replenishment plates to separate from each other to form replenishment openings according to the replenishment signal, and cargoes on the unmanned aerial vehicle enter the storage cabinet via the replenishment openings; manual operations can be avoided in the whole process, and point-to-point smart express receiving between the express receiving cabinet and the unmanned aerial vehicle can be achieved.