The invention discloses an automatic analysis method for a safety isolation measure of secondary protection equipment of an intelligent substation. A primary/secondary equipment correlation model anda virtual loop correlation model between secondary equipment are built on the basis of an SCD model, the secondary equipment relevant to the correlation model is automatically acquired according to the correlation model with regard to primary equipment needed to be powered off, other secondary equipment relevant to a secondary virtual loop is searched with regard to the secondary equipment to be maintained, safety measure operation by which the maintained secondary equipment can be reliably isolated according to a safety measure principle of the secondary equipment under a power failure or non-power failure condition, and whether the safety measure operation is safe and reliable is further efficiently detected.