The invention discloses a high-voltage power distribution cabinet, which comprises a cabinet body. A cabinet door is arranged at the front portion of the cabinet body. The top plate and the rear plateof the cabinet body are solid. The upper portions of a left side plate and a right side plate of the cabinet body are solid, the lower portions of the left side plate and the right side plate of thecabinet body are of hollow cavity structures, and the thickness of the lower portions of the left side plate and the right side plate of the cabinet body is larger than that of the upper portions. Multiple layers of filter screens for dust filtering are arranged in the hollow cavities of the left side plate and the right side plate of the cabinet body. Multiple air inlets are formed in the lower portions of the left side plate and the right side plate, a base plate of the cabinet body is of a hollow cavity structure and is communicated with the hollow cavity structures of the left side plate and the right side plate, and multiple air outlets are formed in the upper surface of the base plate of the cabinet body. Multiple horizontal partition plates are arranged inside the cabinet body, andmultiple through holes are formed in the horizontal partition plates in the vertical direction. Multiple heat dissipation holes are formed in the top plate of the cabinet body. In addition, the high-voltage power distribution cabinet further comprises a round rain-blocking canopy and a cylindrical waterproof device. The problems of water proofing, heat dissipation and dust proofing of the power distribution cabinet are effectively solved.