The invention discloses an application of protein OsZFP213 in regulating plant stress resistance. The provided protein OsZFP213 is a1), a2) or a3), wherein a1) is protein with the amino acid sequenceshown in a sequence 2 in a sequence list; a2) is fusion protein obtained by bonding a N-terminal or/and C-terminal of the protein shown in the sequence 2 in the sequence list with a label; a3) is protein which is obtained through replacement and/or deficiency and/or addition of one or more amino acid residues in the amino acid sequence shown in the sequence 2 in the sequence list and is related toplant stress resistance. Experiments prove that OsZFP213 transgenic rice is obtained through overexpression of an OsZFP213 gene in rice variety Zhonghua 10; compared with the rice variety Zhonghua 10, the OsZFP213 transgenic rice has enhanced stress resistance. Therefore, the protein OsZFP213 has great theoretical significance and practical value in culturing plants with the enhanced stress resistance.