The invention provides a compound with necrocytosis inhibitory activity. The compound with necrocytosis inhibitory activity and the pharmacologically acceptable salt of the compound have the structureshown in general formula I as shown in the specification. The invention further provides a pharmaceutical composition which comprises the compound with necrocytosis inhibitory activity or the pharmacologically acceptable salt of the compound. The invention also provides application of the compound with necrocytosis inhibitory activity or the pharmacologically acceptable salt of the compound in preparation of drugs for treating and preventing necrocytosis related systemic inflammatory response, tumors, metabolism diseases and neurodegenerative diseases such as cerebral ischemia and stroke. Thecompound with necrocytosis inhibitory activity, the pharmacologically acceptable salt of the compound and the composition of the compound with necrocytosis inhibitory activity and the pharmacologically acceptable salt of the compound can effectively inhibit necrocytosis.