The invention discloses a high-voltage driving power supply for a high-energy ion air purifier. The high-voltage driving power supply comprises a voltage-stabilizing frequency converter and a low-frequency boosting transformer that are connected successively. The voltage-stabilizing frequency converter provides a low-frequency alternating-current power supply with the adjustable voltage and frequency for the low-frequency boosting transformer based on purification needs. The low-frequency boosting transformer is used for realizing boosting on the low-frequency alternating-current power supply.The voltage-stabilizing frequency converter consists of a voltage-regulation frequency-modulation module, a control module, a voltage detection module and a current detection module. The output voltage from the high-voltage driving power supply is tracked and given and can be adjusted and thus the high-energy ion energy excited by a high-energy ionizer is higher than the chemical bond energy of gas needing to be purified, so that the chemical bond is broken. The output frequency of the high-voltage driving power supply is determined based on the purification frequency and the ozone concentration, so that the purification efficiency of the high-energy ionizer for gas with different chemical compositions is guaranteed and the concentration of the generated ozone is controlled effectively.