The invention discloses a method for reducing the harm of high-temperature ripening to flue-cured tobacco. The method for reducing the harm of high-temperature ripening to the flue-cured tobacco comprises the steps of: spraying a light-damage preventing and controlling agent, strengthening secondary metabolism of tobacco plants in a mature stage and controlling three factors of light, temperatureand humidity in a late mature stage of the flue-cured tobacco in a coordinated mode. By spraying the light-damage preventing and controlling agent and a secondary metabolite inducer to the flue-curedtobacco in an area which suffers from the harm of high-temperature ripening and controlling the three factors of light, temperature and humidity in the late mature stage of the flue-cured tobacco in acoordinated mode on the area, the harm of high temperature ripening to the flue-cured tobacco can be reduced, higher yield and quality can be obtained, and better economic benefits can be achieved.