The invention belongs to the technical field of oil field mining equipment, and particularly relates to a high energy negative pressure plug removing device. The high energy negative pressure plug removing device comprises an exploder joint, a solid fuel tray and a fixing nut and further comprises a negative pressure cabin body, a large aperture middle connecting part, a delay annular-tangency negative pressure cabin opening device, a cutting cable, a multistage delay partition plate exploder, a solid fuel upper joint, a rocket solid propellant, a gunpowder middle connecting part and a gunpowder trail plugging part. The exploder joint is in threaded connection with the negative pressure cabin body. The negative pressure cabin body is connected with the delay negative pressure cabin openingdevice through threads at the two ends of the large aperture middle connecting part. The multistage delay partition plate exploder is in threaded connection with the delay negative pressure cabin opening device. The rocket solid propellant is connected with a thread of the gunpowder middle connecting part in series through the solid fuel upper joint and then in threaded connection with the multistage delay partition plate exploder. The cutting cable is located in the multistage delay partition plate exploder. The high energy negative pressure plug removing device is suitable for cleaning up the well condition environment in the middle and later stage of mining, and the clean production environment of well vicinity rock gaps, perforation hole channels and the wellhole inner wall can be effectively restored.