The invention discloses a two-section type pneumatic valve set used for large flow filling. The two-section type pneumatic valve set comprises a pneumatic actuator, a cut-off valve, a first electromagnetic valve, a second electromagnetic valve and a filtering reducing valve; the filtering reducing valve is communicated with a first pressure opening P1 of the first electromagnetic valve and a second pressure opening P2 of the second electromagnetic valve through an air way; a first working opening A1 of the first electromagnetic valve is communicated with a first air opening of the pneumatic actuator through an air way, and a second working opening B1 of the first electromagnetic valve is communicated with a second air opening of the pneumatic actuator through an air way; and a third working opening A2 of the second electromagnetic valve is communicated with a third air opening of the pneumatic actuator through an air way, and a fourth working opening B2 of the second electromagnetic valve is communicated with a fourth air opening of the pneumatic actuator through an air way. The invention further discloses a method for conducting large-flow two-step filling through the above two-section type pneumatic valve set. By means of the two-section type pneumatic valve set and the method, large-flow two-step material filling can be achieved, storage tank or powder bin overflowing is prevented, operation is simple, control is flexible, maintenance is convenient, and automatic control can be achieved.