The invention discloses a dispensing method, a cloud center server, a dispensing box and a dispensing system; the dispensing method comprises the following steps: obtaining scanning data by using a dispensing box scanner to scan a corresponding label on an item; receiving a packaging finished order of the dispensing box, forming a cartonning two dimensional code according to the scanning data, andsending the two dimensional code to the dispensing box display; obtaining the first scanning data by using a consigner terminal to scan the cartonning two dimensional code, thus confirming the consignment; obtaining the second scanning data by using a delivery man terminal to scan the cartonning two dimensional code, thus starting the delivery; forming a dispensing two dimensional code accordingto the first scanning data and the second scanning data, and sending the dispensing two dimensional code to a delivery box display; obtaining the third scanning data by using a consignee terminal to scan the dispensing two dimensional code; verifying the consignee according to the third scanning data, and sending an unpack control instruction to the delivery box after the verification succeeds. The method can ensure the goods safety by creating a voucher between the consignee and the consigner, wherein the voucher cannot be tampered.