The invention provides an interlocking table automatic generation method and device. The interlocking table automatic generation method comprises the steps that target station information is obtained,and a station data node drawing is generated according to the target station information; signal machine nodes in the station data node drawing are traversed so as to determine beginning terminal nodes and terminal nodes of various accesses; the beginning terminal node of each access serves as a beginning point, an access node set is initialized, all connecting nodes are sequentially traversed along the edge where the beginning terminal node of each access is located, information of all the traversed connecting nodes is recorded, and all the traversed connecting nodes are stored into the access node set; the access node set is searched so as to obtain an access set; after searching of the access node set is finished, according to the interlocking relation composition, all the nodes in theaccess set are traversed; and information in the traversed access set is output and converted into a standardized interlocking table.