The invention discloses a bonding method of neoprene and brass in a waterproof connector. The bonding method comprises the following steps: sequentially adding neoprene 2442, an accelerator SAD, MgO,a resorcinol donor SL-3022, an anti-aging agent RD, an anti-aging agent 4010 and cobalt decanoate Co20 into a mixer for mixing for 1 min; adding carbon black N550 into the mixer for mixing for 1 min;simultaneously adding white carbon black and aromatic oil V700 into the mixer for mixing for 1 min; after an upper top peg is opened for 10 s, descending the upper top peg, mixing for 50-60 S and continuously repeating the step three times; after the temperature of compound is 110 DEG C and is stabilized for 30 S, and discharging rubber compound; cooling for 2-3 h, sequentially adding a methylenedonor RA-65, a vulcanization accelerator DM, sulfur and ZnO for mixing, performing batch-out treatment and cooling for standby application, wherein a sizing material after cooling is used for vulcanization and bonding with the brass. A prepared bonding material of the neoprene and the brass has comparatively high initial bonding force and comparatively high corrosion resistance and a vulcanizationsizing material has comparatively high breaking strength.